Renal Cell Carcinoma Marker 腎細胞癌標記

廣州健侖生物科技有限公司

RCC在90％以上原發性腎細胞癌、 80％左右轉移性腎細胞癌陽性表達。與CD10可聯合用于轉移性腎細胞癌的研究。RCC還表達于乳腺腺泡和導管上皮細胞的腔面、附睪上皮細胞及甲狀旁腺主細胞內、甲狀腺濾泡內的膠質。

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Renal Cell Carcinoma Marker 腎細胞癌標記

【產品介紹】

細胞定位：細胞漿/細胞膜

克隆號：66.4.C2

同型：IgG

適用組織：石蠟/冰凍

陽性對照：腎細胞癌/正常腎

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

近日，來自牛津大學的科學家通過研究，揭示了控制機體上皮細胞形狀和運動狀態發生轉變的關鍵機制，相關研究刊登于雜志Nature Cell biology上;文章中研究者表示，名為ASPP2的腫瘤抑制蛋白的功能就好比是一種分子開關，其可以控制并且逆轉機體上皮細胞的形狀及運動狀態的改變，這對于解釋一系列生化現象，比如傷口愈合、胚胎發育及癌癥轉移都非常關鍵。
研究者Xin Lu表示，目前我們盡力去鑒別出控制控制上皮細胞可塑性的分子開關，這樣的可塑性是癌癥的標志，為了發生轉移，癌細胞會疏松自身的結構，不斷擺動脫離母體腫瘤組織，進而在機體其它組織器官部位“安家”，上述的過程就稱為上皮細胞向間充質細胞的轉分化過程及間質細胞向上皮細胞的轉化過程(EMT及MET)。
研究者發現，在腎小管的發育過程中ASPP2蛋白會促使MET過程的發生，從而過濾掉機體血液中的廢棄物，而當ASPP2蛋白缺失時會促進EMT過程的發生，尤其是在表達常見癌癥基因RAS細胞中，EMT過程尤為明顯，從而就會引發癌癥發生轉移。隨后研究人員對小鼠模型進行試驗發現，當小鼠機體中抗原抗體癌細胞表達較低水平的ASPP2時，其就會大量轉移至大腦細胞中，如果這些抗原抗體癌細胞表達較足量的ASPP2，其轉移的能力就會明顯下降。

Recently, scientists from Oxford University revealed the key mechanisms that control the change of the epithelial cell shape and movement in the body. Relevant research is published in the journal Nature Cell Biology. In the article, researchers said that the tumor suppressor protein called ASPP2 Is like a molecular switch that controls and reverses changes in the shape and motility of the body's epithelium, which is crucial for interpreting a range of biochemical phenomena such as wound healing, embryonic development, and cancer metastasis.
Xin Lu, a researcher, said that at present we try our best to identify molecular switches that control the plasticity of epithelial cells. Such plasticity is a hallmark of cancer. In order to metastasize, cancerous cells loose their structure and constantly swing away from the mother's tumor tissue, Other parts of the body organs "home", the above process is called the epithelial cells to mesenchymal cells transdifferentiation process and the conversion of stromal cells to epithelial cells (EMT and MET).
The researchers found that during the development of tubules, ASPP2 protein can promote the occurrence of MET process and thus filter out the body's blood waste, and when ASPP2 protein is missing, it can promote EMT process, especially in the expression of common cancer genes RAS cells, the EMT process is particularly evident, which will trigger the transfer of cancer. Subsequently, researchers conducted experiments on mouse models and found that when the antigen-antibody-expressing cancer cells in the mouse body express a lower level of ASPP2, they can be largely transferred to the brain cells. If these antigen-antibody-expressing cancer cells express a sufficient amount of ASPP2 , Its ability to transfer will be significantly reduced.